期刊
JOURNAL OF FUNCTIONAL BIOMATERIALS
卷 4, 期 3, 页码 114-161出版社
MDPI
DOI: 10.3390/jfb4030114
关键词
decellularization; extracellular matrix; cornea; tissue engineering
资金
- E-TERM Engineering, Tissue Engineering and Regenerative Medicine [EP/I017801/1]
- EPSRC [EP/I017801/1] Funding Source: UKRI
The worldwide limited availability of suitable corneal donor tissue has led to the development of alternatives, including keratoprostheses (Kpros) and tissue engineered (TE) constructs. Despite advances in bioscaffold design, there is yet to be a corneal equivalent that effectively mimics both the native tissue ultrastructure and biomechanical properties. Human decellularized corneas (DCs) could offer a safe, sustainable source of corneal tissue, increasing the donor pool and potentially reducing the risk of immune rejection after corneal graft surgery. Appropriate, human-specific, decellularization techniques and high-resolution, non-destructive analysis systems are required to ensure reproducible outputs can be achieved. If robust treatment and characterization processes can be developed, DCs could offer a supplement to the donor corneal pool, alongside superior cell culture systems for pharmacology, toxicology and drug discovery studies.
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