期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 33, 期 11, 页码 1991-1997出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfy034
关键词
cardiovascular disease; end-stage renal disease; infection; kidney transplantation; mannose-binding lectin
Background. Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannosebinding lectin (MBL) has been suggested to play a protective role in this regard. The aimof this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft. Methods. A total of 98 patients with ESRD accepted for livingdonor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7.5-9.9). Medical records were evaluated regarding transplantation status, diabetesmellitus, vascular parameters and infections for all the patients. Cox regression models and logistic regression analysis were used for statistical analyses. The cohort was divided into two groups according to the MBL2 genotype (normal A/A versus variant A/O or O/O). Results. We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections). Conclusion. In this cohort, the MBL2 genotype did not seem to be associated with any long-term clinical effects in ESRD patients on dialysis or with a functioning graft.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据