期刊
NEPHROLOGY
卷 23, 期 6, 页码 530-538出版社
WILEY
DOI: 10.1111/nep.13068
关键词
Ascorbic acid; Contrast-induced nephropathy; Coronary angiography; meta-analysis; N-acetylcysteine
资金
- Special Health Project of Jilin Province
- Project of Industry Technology Research and Development of Jilin Province [2015Y036-1, 2016C041-2]
AimThe purpose of the present study was to evaluate the efficacy of N-acetylcysteine (NAC) versus ascorbic acid (VC) or NAC plus (+) VC on the prevention of contrast-induced nephropathy (CIN) in patients undergoing contrast administration. MethodsWe searched databases including Medline, Embase and Cochrane Library up to Feb 22 (th), 2017. Pooled risk ratios (RRs) or weighted mean difference (WMD) with their 95% confidence intervals (CIs) were calculated using fixed-effects model or random-effects model when appropriate. All analyses were performed using the Review Manager 5.2. ResultsA totalof six randomized controlled trials including 919 patients (478 cases received NAC administration and 441 cases received VC or NAC+VC administration) were considered in the meta-analysis. Results showed that there was no significant difference in preventing CIN between NAC and NAC+VC administration as well as between NAC and VC administration. In addition, significant difference was found in serum creatinine level between NAC and VC or NAC+VC administration (WMD=-0.31, 95% CI: -0.48 to -0.14, P=0.0003) as well as NAC and VC administration (WMD=-0.05, 95% CI: -0.08 to -0.02, P=0.002). Besides, NAC and NAC+VC administration also has significant difference (WMD=-0.72, 95% CI: -1.33 to -0.11, P=0.02). ConclusionIn conclusion, the prevention effect of NAC administration and VC or NAC+VC administration on CIN was similar in patients undergoing contrast administration. But NAC administration was associated with a significantly lower serum creatinine levels compared to VC and NAC+VC administration. Summary at a Glance Contrast-induced nephropathy (CIN) is a common and serious side effect in patients undergoing cardioangiography or radiological procedures. N-acetylcysteine is an option in preventing CIN.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据