期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 25, 期 2, 页码 135-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-017-0020-6
关键词
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资金
- European Research Council (ERC) Starting Grant ANTIVIRNA [ERC-StG-337284]
- European Molecular Biology Organization [EMBO ALTF-343-2013]
- European Union 7th Framework Program (PROSPECTS) [HEALTH-F4-2008-201648]
- European Research Council (ERC) [233226, 670821]
- Innovative Medicines Initiative Joint Undertaking (ULTRA-DD) [115766]
- Howard Hughes Medical Institute
- Vallee Foundation
Mammalian mRNA biogenesis requires specific recognition of a hexanucleotide AAUAAA motif in the polyadenylation signals (PAS) of precursor mRNA (pre-mRNA) transcripts by the cleavage and polyadenylation specificity factor (CPSF) complex. Here we present a 3.1-angstrom-resolution cryo-EM structure of a core CPSF module bound to the PAS hexamer motif. The structure reveals the molecular interactions responsible for base-specific recognition, providing a rationale for mechanistic differences between mammalian and yeast 3' polyadenylation.
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