期刊
NATURE REVIEWS RHEUMATOLOGY
卷 14, 期 7, 页码 393-403出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41584-018-0033-5
关键词
-
类别
资金
- National Science Foundation [NSF-1536463]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1536463] Funding Source: National Science Foundation
Developing therapeutic molecules that target chondrocytes and locally produced inflammatory factors within arthritic cartilage is an active area of investigation. The extensive studies that have been conducted over the past 50 years have enabled the accurate prediction and reliable optimization of the transport of a wide variety of molecules into cartilage. In this Review, the factors that can be used to tune the transport kinetics of therapeutics are summarized. Overall, the most crucial factor when designing new therapeutic molecules is solute size. The diffusivity and partition coefficient of a solute both decrease with increasing solute size as indicated by molecular mass or by hydrodynamic radius. Surprisingly, despite having an effective pore size of similar to 6 nm, molecules of similar to 16 nm radius can diffuse through the cartilage matrix. Alteration of the shape or charge of a solute and the application of physiological loading to cartilage can be used to predictably improve solute transport kinetics, and this knowledge can be used to improve the development of therapeutic agents for osteoarthritis that target the cartilage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据