期刊
NATURE REVIEWS NEUROSCIENCE
卷 19, 期 4, 页码 185-196出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2018.8
关键词
-
资金
- US National Institutes of Health [DK082480, DK093848]
The CNS regulates body weight; however, we still lack a clear understanding of what drives decisions about when, how much and what to eat. A vast array of peripheral signals provides information to the CNS regarding fluctuations in energy status. The CNS then integrates this information to influence acute feeding behaviour and long-term energy homeostasis. Previous paradigms have delegated the control of long-term energy homeostasis to the hypothalamus and short-term changes in feeding behaviour to the hindbrain. However, recent studies have identified target hindbrain neurocircuitry that integrates the orchestration of individual bouts of ingestion with the long-term regulation of energy balance.
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