期刊
NATURE REVIEWS NEUROLOGY
卷 14, 期 5, 页码 259-271出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneurol.2018.23
关键词
-
资金
- National Health and Medical Research Council of Australia (NHMRC) programme [1037746]
- Australian Research Council Centre of Excellence in Cognition and its Disorders Memory Program [CE110001021]
- NHMRC [1003139, 1081916]
- Royal Australasian College of Physicians Vincent Fairfax family fellowship
The effects of neurodegenerative syndromes extend beyond cognitive function to involve key physiological processes, including eating and metabolism, autonomic nervous system function, sleep, and motor function. Changes in these physiological processes are present in several conditions, including frontotemporal dementia, amyotrophic lateral sclerosis, Alzheimer disease and the parkinsonian plus conditions. Key neural structures that mediate physiological changes across these conditions include neuroendocrine and hypothalamic pathways, reward pathways, motor systems and the autonomic nervous system. In this Review, we highlight the key changes in physiological processing in neurodegenerative syndromes and the similarities in these changes between different progressive neurodegenerative brain conditions. The changes and similarities between disorders might provide novel insights into the human neural correlates of physiological functioning. Given the evidence that physiological changes can arise early in the neurodegenerative process, these changes could provide biomarkers to aid in the early diagnosis of neurodegenerative diseases and in treatment trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据