期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 5, 页码 297-312出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.127
关键词
-
类别
资金
- Swiss National Science Foundation [310030B-149641]
- R01 research grant from the US National Institutes of Health [GM 114119]
- American Cancer Society Scholar Grant [129742-RSG-16-156-01-CCG]
- March of Dimes Research Grant [1-FY17-698]
Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule-related processes, including motility, cell division and cell signalling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new centriole is formed next to each pre-existing centriole in every cell cycle. Advances in imaging, proteomics, structural biology and genome editing have revealed new insights into centriole biogenesis, how centriole numbers are controlled and how alterations in these processes contribute to diseases such as cancer and neurodevelopmental disorders. Moreover, recent work has uncovered the existence of surveillance pathways that limit the proliferation of cells with numerical centriole aberrations. Owing to this progress, we now have a better understanding of the molecular mechanisms governing centriole biogenesis, opening up new possibilities for targeting these pathways in the context of human disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据