期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 9, 页码 579-593出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0033-y
关键词
-
类别
资金
- National Institute on Aging [R01AG038664, R01AG037514, R01AG049157, R01AG040288]
- National Institute of General Medical Sciences [R01GM117466]
- Ellison Medical Foundation
- American Federation for Aging Research
- UK Dementia Research Institute (Medical Research Council)
- UK Dementia Research Institute (Alzheimer Disease Research UK)
- UK Dementia Research Institute (Alzheimer Disease Society)
- Wellcome Trust [095317/Z/11/Z]
- Rosetrees Trust
- Cambridge Institute for Medical Research [100140/Z/12/Z]
- Alzheimer Disease Research UK
- Tau Consortium
- Biomedical Research Centre at Addenbrooke's Hospital
- MRC [UKDRI-2002] Funding Source: UKRI
Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade indicates that autophagy also has a direct role in modulating ageing. In particular, elegant studies using yeasts, worms, flies and mice have demonstrated a broad requirement for autophagy-related genes in the lifespan extension observed in a number of conserved longevity paradigms. Moreover, several new and interesting concepts relevant to autophagy and its role in modulating longevity have emerged. First, select tissues may require or benefit from autophagy activation in longevity paradigms, as tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan. Second, selective types of autophagy may be crucial for longevity by specifically targeting dysfunctional cellular components and preventing their accumulation. And third, autophagy can influence organismal health and ageing even non-cell autonomously, and thus, autophagy stimulation in select tissues can have beneficial, systemic effects on lifespan. Understanding these mechanisms will be important for the development of approaches to improve human healthspan that are based on the modulation of autophagy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据