期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 6, 页码 349-364出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0003-4
关键词
-
类别
资金
- Deutsche Forschungsgemeinschaft [SFB 1177]
- European Research Council (ERC) advanced grant [742720]
- LOEWE program Ubiquitin Networks (Ub-Net)
- LOEWE Center for Gene and Cell Therapy Frankfurt (CGT)
- Israeli Science Foundation [1247/15]
- Legacy Heritage Fund [1935/16]
- Minerva foundation
- Federal German Ministry for Education and Research
- European Research Council (ERC) [742720] Funding Source: European Research Council (ERC)
Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults. Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据