期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 7, 页码 419-435出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0007-0
关键词
-
类别
资金
- NCI NIH HHS [P30 CA008748, T32 CA160001] Funding Source: Medline
Few cell signals match the impact of the transforming growth factor-beta (TGF beta) family in metazoan biology. TGF beta cytokines regulate cell fate decisions during development, tissue homeostasis and regeneration, and are major players in tumorigenesis, fibrotic disorders, immune malfunctions and various congenital diseases. The effects of the TGF beta family are mediated by a combinatorial set of ligands and receptors and by a common set of receptor-activated mothers against decapentaplegic homologue (SMAD) transcription factors, yet the effects can differ dramatically depending on the cell type and the conditions. Recent progress has illuminated a model of TGF beta action in which SMADs bind genome-wide in partnership with lineage-determining transcription factors and additionally integrate inputs from other pathways and the chromatin to trigger specific cellular responses. These new insights clarify the operating logic of the TGF beta pathway in physiology and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据