期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 6, 页码 382-398出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0004-3
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资金
- National Institutes of Health (NIH) [R01GM107214, R01GM121772]
- Wellcome Trust [WT100387]
- Medical Research Council, UK [MC_UP_A025_1011]
- NIH [R01 GM097312]
- MRC [MC_UP_A025_1011] Funding Source: UKRI
Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here, we focus on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses. A central challenge in the field is to understand how a single motor can transport such a diverse array of cargoes and how this process is regulated. The molecular basis by which each cargo is linked to dynein and its cofactor dynactin has started to emerge. Of particular importance for this process is a set of coiled-coil proteins - activating adaptors - that both recruit dynein-dynactin to their cargoes and activate dynein motility.
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