4.8 Article

High-speed optical coherence tomography by circular interferometric ranging

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NATURE PHOTONICS
卷 12, 期 2, 页码 111-116

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/s41566-017-0088-x

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资金

  1. National Institutes of Health (NIH) [R01CA163528, P41EB015903]
  2. DOD/AFOSR [FA9550-11-1-0331]
  3. Harvard Medical School Bullock Post-Doctoral Fellowship
  4. National Science Foundation (NSF) Graduate Research Fellowships Program [11-031]
  5. Alcon
  6. NATIONAL CANCER INSTITUTE [R01CA163528] Funding Source: NIH RePORTER
  7. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015903] Funding Source: NIH RePORTER

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Existing three-dimensional optical imaging methods excel in controlled environments, but are difficult to deploy over large, irregular and dynamic fields. This means that they can be ill-suited for use in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography to efficiently interrogate sparse scattering fields, that is, those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling. This results in circular ranging, and reduces the number of measurements required to interrogate large volumetric fields. As a result, signal acquisition barriers that have limited speed and field in optical coherence tomography are avoided. With a new ultrafast, time-stretched frequency comb laser design operating with 7.6 MHz to 18.9 MHz repetition rates, we achieved imaging of multi-cm(3) fields at up to 7.5 volumes per second.

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