期刊
NATURE METHODS
卷 15, 期 6, 页码 437-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0007-1
关键词
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资金
- NCI CPTAC PCC [1U24CA210986-01]
- Broad Institute (SPARC grant)
- Pediatric Scientist Development Program
- March of Dimes Birth Defects Foundation
Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.
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