期刊
NATURE IMMUNOLOGY
卷 19, 期 7, 页码 711-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-018-0136-9
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资金
- SNF [PP00P3_150714]
- Novartis Foundation for medical biological research [16A052]
- Swiss National Science Foundation (SNF) [PP00P3_150714] Funding Source: Swiss National Science Foundation (SNF)
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R(+) lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH(+) Ly6D(+) precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R(+) lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen.
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