期刊
NATURE GENETICS
卷 50, 期 3, 页码 362-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-018-0056-5
关键词
-
资金
- Dairy Futures Cooperative Research Centre
- German Federal Ministry of Education and Research (BMBF) within the AgroClustEr 'Synbreed-Synergistic Plant and Animal Breeding' [0315527B]
- European Union (EU) Collaborative Project LowInputBreeds [222623]
- Deutsche Forschungsgemeinschaft (DFG) [PA 2789/1-1]
- Research Stimulus Fund [11/S/112]
- Science Foundation Ireland [14/IA/2576]
- Genome Canada project entitled 'Whole Genome Selection through Genome Wide Imputation in Beef Cattle'
- National Institute of Food and Agriculture, US Department of Agriculture [2013-68004-20364, 2015-67015-23183]
- EU Collaborative Project Quantomics [516, 222664]
- public-private partnership 'Breed4Food' [BO-22.04-011001-ASG-LR]
- EU FP7 IRSES SEQSEL [317697]
- Science Foundation Ireland (SFI) [14/IA/2576] Funding Source: Science Foundation Ireland (SFI)
Stature is affected by many polymorphisms of small effect in humans(1). In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes(2,3). Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 x 10(-8)) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据