期刊
NATURE GENETICS
卷 50, 期 2, 页码 199-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-017-0031-6
关键词
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资金
- EUROTAST Marie Curie Framework Programme 7 Initial Training Network [290344]
- Research Fund of University of Iceland
- Icelandic Research Fund [163428-051]
A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.
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