期刊
HIPPOCAMPUS
卷 25, 期 8, 页码 924-938出版社
WILEY
DOI: 10.1002/hipo.22415
关键词
gamma; hippocampus; running speed; place cells; grid cells
资金
- Esther A., Joseph Klingenstein Fund
- Alfred P. Sloan Foundation
- NIMH [P30 MH089900, 1R01MH102450-01A1, 1F30MH100818-01A1]
- ONR [N00014-14-1-0322]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH102450, F30MH100818, P30MH089900] Funding Source: NIH RePORTER
In hippocampal area CA1 of rats, the frequency of gamma activity has been shown to increase with running speed (Ahmed and Mehta, 2012). This finding suggests that different gamma frequencies simply allow for different timings of transitions across cell assemblies at varying running speeds, rather than serving unique functions. However, accumulating evidence supports the conclusion that slow (approximate to 25-55 Hz) and fast (approximate to 60-100 Hz) gamma are distinct network states with different functions. If slow and fast gamma constitute distinct network states, then it is possible that slow and fast gamma frequencies are differentially affected by running speed. In this study, we tested this hypothesis and found that slow and fast gamma frequencies change differently as a function of running speed in hippocampal areas CA1 and CA3, and in the superficial layers of the medial entorhinal cortex (MEC). Fast gamma frequencies increased with increasing running speed in all three areas. Slow gamma frequencies changed significantly less across different speeds. Furthermore, at high running speeds, CA3 firing rates were low, and MEC firing rates were high, suggesting that CA1 transitions from CA3 inputs to MEC inputs as running speed increases. These results support the hypothesis that slow and fast gamma reflect functionally distinct states in the hippocampal network, with fast gamma driven by MEC at high running speeds and slow gamma driven by CA3 at low running speeds. (c) 2015 Wiley Periodicals, Inc.
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