相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
Johnny Habchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Molecular mechanisms of protein aggregation from global fitting of kinetic models
Georg Meisl et al.
NATURE PROTOCOLS (2016)
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Celine Galvagnion et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
Paolo Arosio et al.
NATURE COMMUNICATIONS (2016)
Nanoscale studies link amyloid maturity with polyglutamine diseases onset
F. S. Ruggeri et al.
SCIENTIFIC REPORTS (2016)
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease
Johnny Habchi et al.
SCIENCE ADVANCES (2016)
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
Georg Meisl et al.
SCIENTIFIC REPORTS (2016)
Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
Thomas C. T. Michaels et al.
JOURNAL OF CHEMICAL PHYSICS (2015)
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Celine Galvagnion et al.
NATURE CHEMICAL BIOLOGY (2015)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Samuel I. A. Cohen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
On the lag phase in amyloid fibril formation
Paolo Arosio et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
Pietro Sormanni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Samuel I. A. Cohen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
The Molecular Structure of Alzheimer β-Amyloid Fibrils Formed in the Presence of Phospholipid Vesicles
Zheng Niu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Interaction of Alzheimer's β-Amyloid Peptides with Cholesterol: Mechanistic Insights into Amyloid Pore Formation
Coralie Di Scala et al.
BIOCHEMISTRY (2014)
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
W. Gibson Wood et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Spotlights on Recent JACS Publications
ACS Contributing Correspondents
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
The amyloid state and its association with protein misfolding diseases
Tuomas P. J. Knowles et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
Soyon Hong et al.
NEURON (2014)
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Georg Meisl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Chemical kinetics for drug discovery to combat protein aggregation diseases
Paolo Arosio et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
Julius Popp et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Samuel I. A. Cohen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Solubility of cholesterol in lipid membranes and the formation of immiscible cholesterol plaques at high cholesterol concentrations
Matthew A. Barrett et al.
SOFT MATTER (2013)
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
Jean E. Vance
DISEASE MODELS & MECHANISMS (2012)
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
Elisa Evangelisti et al.
JOURNAL OF CELL SCIENCE (2012)
From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
Samuel I. A. Cohen et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Differential Dynamic and Structural Behavior of Lipid-Cholesterol Domains in Model Membranes
Luis F. Aguilar et al.
PLOS ONE (2012)
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations
Samuel I. A. Cohen et al.
JOURNAL OF CHEMICAL PHYSICS (2011)
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
Samuel I. A. Cohen et al.
JOURNAL OF CHEMICAL PHYSICS (2011)
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations
Samuel I. A. Cohen et al.
JOURNAL OF CHEMICAL PHYSICS (2011)
Linking lipids to Alzheimer's disease: cholesterol and beyond
Gilbert Di Paolo et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process
Erik Hellstrand et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Retardation of Aβ Fibril Formation by Phospholipid Vesicles Depends on Membrane Phase Behavior
Erik Hellstrand et al.
BIOPHYSICAL JOURNAL (2010)
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Guojun Bu
NATURE REVIEWS NEUROSCIENCE (2009)
Effect of cholesterol on the structure of a phospholipid bilayer
Frederick de Meyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
An Analytical Solution to the Kinetics of Breakable Filament Assembly
Tuomas P. J. Knowles et al.
SCIENCE (2009)
Membrane lipids: where they are and how they behave
Gerrit van Meer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-β peptide
Eva Y. Chi et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct
Mihaela Necula et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
A century-old debate on protein aggregation and neurodegeneration enters the clinic
Peter T. Lansbury et al.
NATURE (2006)
High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus
Othman Ghribi et al.
EXPERIMENTAL NEUROLOGY (2006)
Raft lipids as common components of human extracellular amyloid fibrils
GP Gellermann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles
N Kucerka et al.
BIOPHYSICAL JOURNAL (2005)
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
RE Tanzi et al.
CELL (2005)
FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils
G Zandomeneghi et al.
PROTEIN SCIENCE (2004)
The effect of cholesterol on the lateral diffusion of phospholipids in oriented bilayers
A Filippov et al.
BIOPHYSICAL JOURNAL (2003)
Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order
FM Harris et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
Role of apoE/Aβ interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy
DM Holtzman
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
Cholesterol, a modulator of membrane-associated Aβ-fibrillogenesis and neurotoxicity
CM Yip et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice
T Mori et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2001)
Cholesterol metabolism in the brain
JM Dietschy et al.
CURRENT OPINION IN LIPIDOLOGY (2001)