期刊
NATURE CHEMICAL BIOLOGY
卷 14, 期 8, 页码 760-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0078-4
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资金
- EMBO Long Term Fellowship [ALTF 739-2015]
- DFG [FR 3720/1-1]
- European Research Council [311363]
- BBSRC [BB/J004561/1]
- Region Centre, France (BioPROPHARM, CatharSIS grants)
Cyclization reactions that create complex polycyclic scaffolds are hallmarks of alkaloid biosynthetic pathways. We present the discovery of three homologous cytochrome P450s from three monoterpene indole alkaloid-producing plants (Rauwolfia serpentina, Gelsemium sempervirens and Catharanthus roseus) that provide entry into two distinct alkaloid classes, the sarpagans and the beta-carbolines. Our results highlight how a common enzymatic mechanism, guided by related but structurally distinct substrates, leads to either cyclization or aromatization.
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