期刊
NATURE CHEMICAL BIOLOGY
卷 14, 期 9, 页码 837-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0097-1
关键词
-
资金
- National Institutes of Health (NIH) [R37 GM086868, R01 GM107047, P01 CA196539]
- NIH [1F32GM110880, 5F32CA206418]
Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据