期刊
NATURE CHEMICAL BIOLOGY
卷 14, 期 6, 页码 530-537出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0056-x
关键词
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资金
- Wyss Institute for Biologically Inspired Engineering
- Paul G. Allen Frontiers Group
- Defense Threat Reduction Agency [HDTRA1-14-1-0006]
- Air Force Office of Scientific Research [FA9550-14-1-0060]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2018R1C1B3007409]
- Marine Biotechnology Program (Marine BioMaterials Research Center) - Ministry of Oceans and Fisheries, Korea
- University of Texas System Rising STARs Program
- Welch Foundation [BP-0037]
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in bio-containment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.
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