期刊
NATURE CHEMICAL BIOLOGY
卷 14, 期 5, 页码 480-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0033-4
关键词
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资金
- Spanish Ministry for Science and Innovation [BIO2016-77216-R]
- Ministerio de Educacion, Spain [AP2010-1410]
- EMBO Short Term Fellowship [ASTF 385-2013]
- MEXT KAKENHI [JP15K21758, JP25113009]
- Swiss National Science Foundation [31003A_169278]
- Grants-in-Aid for Scientific Research [15K21758, 25113009] Funding Source: KAKEN
- Swiss National Science Foundation (SNF) [31003A_169278] Funding Source: Swiss National Science Foundation (SNF)
The phytohormone jasmonoyl-isoleucine (JA-Ile) regulates defense, growth and developmental responses in vascular plants. Bryophytes have conserved sequences for all JA-Ile signaling pathway components but lack JA-Ile. We show that, in spite of 450 million years of independent evolution, the JA-Ile receptor COI1 is functionally conserved between the bryophyte Marchantia polymorpha and the eudicot Arabidopsis thaliana but COI1 responds to different ligands in each species. We identified the ligand of Marchantia MpCOI1 as two isomeric forms of the JA-Ile precursor dinor-OPDA (dinor-cis-OPDA and dinor-iso-OPDA). We demonstrate that AtCOI1 functionally complements Mpcoi1 mutation and confers JA-Ile responsiveness and that a single-residue substitution in MpCOI1 is responsible for the evolutionary switch in ligand specificity. Our results identify the ancestral bioactive jasmonate and clarify its biosynthetic pathway, demonstrate the functional conservation of its signaling pathway, and show that JA-Ile and COI1 emergence in vascular plants required co-evolution of hormone biosynthetic complexity and receptor specificity.
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