期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 24, 页码 3533-3540出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1481837
关键词
Acetylcholinesterase inhibitors; marine bioprospecting; cembranes; marine natural products; Eunicea knigthi; Pseudoplexaura porosa
资金
- Departamento Administrativo de Ciencia, Tecnologia e Innovacion [321-2011]
- Direccion de Investigacion, Universidad Nacional de Colombia [12529]
The acetylcholinesterase inhibitory activity of 89 organic extracts from marine organisms was evaluated through a TLC bioautography methodology. Extracts from soft corals (Eunicea and Plexaura) were the most active compared with extracts from sponges. The bioguided chemical study of the most active extract, obtained from Pseudoplexaura porosa, led to the isolation of a diterpene with spectroscopic properties consistent to those published to the cembrane Steylolide. However, further analysis by X-ray diffraction indicated that the compound was the 14-acetoxycrassine (1), correcting the structure reported to the Styelolide. Additionally, the acetylcholinesterase inhibitory activity of fourteen cembranoids (2?15) isolated from soft corals Eunicea knighti and Pseudoplexaura flagellosa was evaluated. Cembranoids 2, 3 and 4 were the most active compounds in the TLC bioassay. Then, the most promising cembranoids, 14-acetoxycrassine (1) and asperdiol (2), were tested quantitatively and they exhibited IC50 values of 1.40???0.113 and 0.358???0.130??M, respectively.
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