期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 9, 页码 1340-1344出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1475385
关键词
Marine sponge; Dactylospongia elegans; steroids; cytotoxicity; X-ray crystal analysis
资金
- National Natural Science Fund of China [U1605221, 41376155, 21672084, 41476121, 41576130, 81741151]
- Guangzhou Science and Technology Project [201704030042]
A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5 alpha,8 alpha-epidioxy-cholest-6-en-3 beta-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 mu M, respectively. [GRAPHICS] .
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