期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 11, 页码 1605-1611出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1428592
关键词
Gynostemma pentaphyllum; anti-hepatic fibrosis; Cardiomyocytes oxidative injury
资金
- National Natural Science Foundation of China [81703389]
- Education Fund Item of Liaoning Province [201610163L35]
- Youth Development Support Plan of Shenyang Pharmaceutical University [ZQN2016023]
- Innovative training program for College Students of Shenyang Pharmaceutical University
Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. [GRAPHICS] .
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