期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 12, 页码 1727-1733出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1434645
关键词
Polygonatum cyrtonema Hua; homoisoflavone; cytotoxicity
资金
- Yunnan Science and Technology Agency [2016RA030]
- Major science and technology projects (agriculture) [2017AB002]
- National Natural Science Foundation of China [31560010]
- 'The Fundamental Research Funds for the Central Universities', South-Central University for Nationalities [CZQ17010, CZP17094, CSP17061, CSP17067]
A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2 '-hydroxy-4 '-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2-15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin. [GRAPHICS] .
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