期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 18, 页码 2623-2630出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1463223
关键词
Polyhydroxysteroids; glycosides; starfish; Choriaster granulatus; cytotoxicity; immunomodulatory activity
资金
- Russian Foundation for Basic Research [17-04-00034]
Two new steroid glycosides, granulatosides D (1) and E (2), belonging to the group of bi- and monoglycosides of polyhydroxysteroids, respectively, were isolated from the ethanolic extract of the starfish Choriaster granulatus along with thirteen previously known glycosides of polyhydroxysteroids (3-15) and one steroid heptaol (16). The structures of the new compounds were elucidated by extensive NMR and ESIMS techniques. Cytotoxic and immunomodulatory activities of compounds 1, 3-8, and 10-16 using murine splenocytes and peritoneal macrophages were studied. At a dose of 0.1 mu M new glycoside 1 showed immunomodulatory properties, increasing the intracellular ROS (reactive oxygen species) level in peritoneal murine macrophages by 20% and decreasing intracellular ROS level by 21% in pre-treated with endotoxic lipopolysaccharide from E. coli (LPS) peritoneal macrophages. [GRAPHICS] .
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