期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 3, 页码 386-392出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1455041
关键词
Deep-sea derived fungus; Stachybotrys sp; phenylspirodrimanes; cytotoxicity
资金
- Natural Science Foundation of Fujian Province [2016J01369]
- Middle & Young Teacher Education Project of Fujian Province [JA15215]
- Startup Fund for Scientific Research, Fujian Medical University [2016QH015]
Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2-8, 10-13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9-12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC50 in the range of 18.5-52.8 mu M. [GRAPHICS] .
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