期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 3, 页码 340-346出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1452000
关键词
Magnoliaceae; lignan; Schisandra chinensis; natural products; cytotoxicity
资金
- National Natural Science Foundation [81473325]
A new lignan named schilignan F (1), together with twelve known ones (2-13), were isolated from the rattan stems of Schisandra chinensis. Their chemical structures were elucidated by spectroscopic methods including one and two-dimensional NMR spectra referring to the literatures as well as high-resolution mass spectrometric analysis. All compounds were evaluated for their cytotoxicities against human Hela cancer cell lines in vitro. The results showed that compounds 2, 6 and 8 exhibited weak cytotoxic activity with IC50 values of 30.6, 86.3 and 41.0 mu M, and cisplatin showed cytotoxic activity with IC50 value of 27.3 mu M. [GRAPHICS] .
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