期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 17, 页码 2466-2470出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1452012
关键词
Penicillium sp; sponge-associated fungi; lactone derivative; antibacterial activity
资金
- National Natural Science Foundation of China [41776168, 41706167]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201737271]
- Ningbo Science & Technology Projects for Common Wealth [2015C10026, 2017C10016]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- K. C. Wong Magna Fund in Ningbo University
One novel 7-membered lactone derivative, penicillilactone A (1), together with two known compounds, rugulosin A (2) and rugulosin (3) were isolated from the sponge-derived fungus Penicillium sp. LS54. Their structures were elucidated on the basis of spectroscopic analysis and comparison with literature data. Remarkably, penicillilactone A (1) is the first natural product containing a 7-membered lactone ring fused with a furan core. Penicillilactone A (1) exhibited moderate antibacterial activity against aquatic pathogen Vibrio harveyi with an MIC value of 8 mu g/mL. [GRAPHICS] .
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