期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 3, 页码 347-353出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1452001
关键词
Penicillium oxalicum; polyketide; penicilloxalone; anti-neuroinflammatory activity
资金
- National Natural Science Foundation of China [81573572]
- Program for New Century Excellent Talents in University [NCET-13-0693]
- Science and Technology Innovation Fund from Beijing Academy of Agriculture and Forestry Sciences [QNJJ201519]
Two new polyketides, penicilloxalones A (1) and B (2), together with 13 known compounds (3-15), were isolated from the ethyl acetate extract of the solid substrate fermentation cultures of the fungus Penicillium oxalicum MHZ153. The structures of the isolates were determined by spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 7 and 11 showed inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values of 0.9 +/- 0.2 mu M and 87.9 +/- 0.7 mu M, respectively. [GRAPHICS] .
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