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Biosynthesis of (-)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein
Christopher S. Neumann et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
Cai-Guang Yang et al.
NATURE (2008)
Versatility of biological non-heme Fe(II) centers in oxygen activation reactions
Elena G. Kovaleva et al.
NATURE CHEMICAL BIOLOGY (2008)
Expanding chemical biology of 2-oxoglutarate oxygenases
Christoph Loenarz et al.
NATURE CHEMICAL BIOLOGY (2008)
Ethylene production by metabolic engineering of the yeast Saccharomyces cerevisiae
I. Pirkov et al.
METABOLIC ENGINEERING (2008)
Crystal structure of the non-heme iron dioxygenase PtIH in pentalenolactone biosynthesis
Zheng You et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula
Aishwarya V. Ramaswamy et al.
JOURNAL OF NATURAL PRODUCTS (2007)
A-102395, a new inhibitor of bacterial translocase I, produced by Amycolatopsis sp SANK 60206
Ryo Murakami et al.
JOURNAL OF ANTIBIOTICS (2007)
Cloning and characterization of the biosynthetic gene cluster for kutznerides
Danica Galonic Fujimori et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide
Joshua A. V. Blodgett et al.
NATURE CHEMICAL BIOLOGY (2007)
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Stanley S. Ng et al.
NATURE (2007)
Non-heme Fe(IV)-oxo intermediates
Carsten Krebs et al.
ACCOUNTS OF CHEMICAL RESEARCH (2007)
The diverse and pervasive chemistries of the α-keto acid dependent enzymes
Vincent Purpero et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2007)
Nucleoside natural products and related analogs with potential therapeutic properties as antibacterial and antiviral agents
Satoshi Ichikawa et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2007)
Roles of VioG and VioQ in the incorporation and modification of the capreomycidine residue in the peptide antibiotic viomycin
Xiaobo Fei et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Mechanistic and structural basis of stereospecific Cβ-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide
Matthias Strieker et al.
ACS CHEMICAL BIOLOGY (2007)
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3
Danica P. Galonic et al.
NATURE CHEMICAL BIOLOGY (2007)
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid
John T. Whitteck et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Enzymatic generation of the antimetabolite γ,γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete
Masashi Ueki et al.
CHEMISTRY & BIOLOGY (2006)
Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase
Lee M. Hoffart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes
Michael L. Neidig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural biology and chemistry of the terpenoid cyclases
David W. Christianson
CHEMICAL REVIEWS (2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
Ottar Sundheim et al.
EMBO JOURNAL (2006)
Pentalenolactone biosynthesis.: Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis
Zheng You et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis
Charles N. Tetzlaff et al.
BIOCHEMISTRY (2006)
Stalking intermediates in oxygen activation by iron enzymes: Motivation and method
JM Bollinger et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Biosynthesis of the terpene phenalinolactone in Streptomyces sp Tu6071:: Analysis of the gene cluster and generation of derivatives
C Dürr et al.
CHEMISTRY & BIOLOGY (2006)
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
Ian J. Clifton et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Halogenation of unactivated carbon centers in natural product biosynthesis: Trichlorination of leucine during barbamide biosynthesis
DP Galonic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
LC Blasiak et al.
NATURE (2006)
Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB
B Yu et al.
NATURE (2006)
Recent advances in the Stevens rearrangement of ammonium ylides. Application to the synthesis of alkaloid natural products
JA Vanecko et al.
TETRAHEDRON (2006)
Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis
Ioanna Ntai et al.
CHEMICAL COMMUNICATIONS (2006)
JmjC-domain-containing proteins and histone demethylation
Robert J. Klose et al.
NATURE REVIEWS GENETICS (2006)
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease
MA McDonough et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of taurine:: α-ketoglutarate dioxygenase (TauD) from Escherichia coli
JM Bollinger et al.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2005)
Investigating β-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins
B Haltli et al.
CHEMISTRY & BIOLOGY (2005)
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination
CJ Dong et al.
SCIENCE (2005)
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
FH Vaillancourt et al.
NATURE (2005)
SyrB2 in syringomycin E biosynthesis is a nonherne FeII α-ketoglutarate- and O2-dependent halogenase
FH Vaillancourt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Biosynthetic origins of C-P bond containing tripeptide K-26
I Ntai et al.
ORGANIC LETTERS (2005)
Kinetic dissection of the catalytic mechanism of taurine:: α-ketoglutarate dioxygenase (TauD) from Escherichia coli
JC Price et al.
BIOCHEMISTRY (2005)
Effects of fenugreek seed extract in obese mice fed a high-fat diet
T Handa et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)
The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes
KD Koehntop et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2005)
Rapid freeze-quench 57Fe Mossbauer spectroscopy:: Monitoring changes of an iron-containing active site during a biochemical reaction
C Krebs et al.
INORGANIC CHEMISTRY (2005)
Natural products to drugs: daptomycin and related lipopeptide antibiotics
RH Baltz et al.
NATURAL PRODUCT REPORTS (2005)
Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism
RWD Welford et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736
JAV Blodgett et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase
IM Fritze et al.
PLANT PHYSIOLOGY (2004)
Crystal structure of the alkylsulfatase AtsK:: Insights into the catalytic mechanism of the Fe(II) α-ketoglutarate-dependent dioxygenase superfamily
I Müller et al.
BIOCHEMISTRY (2004)
Direct detection of oxygen intermediates in the non-heme Fe enzyme taurine/α-ketoglutarate dioxygenase
DA Proshlyakov et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates
M Costas et al.
CHEMICAL REVIEWS (2004)
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation
M Gunsior et al.
BIOCHEMISTRY (2004)
VioC is a non-heme iron, α-ketoglutarate-dependent oxygenase that catalyzes the formation of 3S-hydroxy-L-arginine during viomycin biosynthesis
XH Yin et al.
CHEMBIOCHEM (2004)
Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway
XH Yin et al.
CHEMBIOCHEM (2004)
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula
ZX Chang et al.
JOURNAL OF NATURAL PRODUCTS (2004)
EXAFS spectroscopic evidence for an Fe=O unit in the Fe(IV) intermediate observed during oxygen activation by taurine:α-ketoglutarate dioxygenase
PJ Riggs-Gelasco et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Biosynthetic gene cluster of the herbicide phosphinothricin tripeptide from Streptomyces viridochromogenes Tu494
D Schwartz et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula
DJ Edwards et al.
CHEMISTRY & BIOLOGY (2004)
Biosynthesis of nonribosomal peptides
R Finking et al.
ANNUAL REVIEW OF MICROBIOLOGY (2004)
Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC
JM Brownlee et al.
BIOCHEMISTRY (2004)
Evidence for hydrogen abstraction from C1 of taurine by the high-spin Fe(IV) intermediate detected during oxygen activation by taurine:α-ketoglutarate dioxygenase (TauD)
JC Price et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Deciphering tuberactinomycin biosynthesis: Isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster
MG Thomas et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms
DK Mercer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Novel proline hydroxylase activities in the pneumocandin-producing fungus Glarea lozoyensis responsible for the formation of trans 3-and trans 4-hydroxyproline
L Petersen et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2003)
The first direct characterization of a high-valent iron intermediate in the reaction of an α-ketoglutarate-dependent dioxygenase:: A high-spin Fe(IV) complex in taurine/α-ketoglutarate dioxygenase (TauD) from Escherichia coli
JC Price et al.
BIOCHEMISTRY (2003)
Crystal structure of carbapenem synthase (CarC)
IJ Clifton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Substrate-induced conformational changes in Escherichia coli taurine/α-ketoglutarate dioxygenase and insight into the oligomeric structure
JR O'Brien et al.
BIOCHEMISTRY (2003)
Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005
DA Widdick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
An FeIV=O complex of a tetradentate tripodal nonheme ligand
MH Lim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Crystallographic and spectroscopic characterization of a nonheme Fe(IV)=O complex
JU Rohde et al.
SCIENCE (2003)
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α
JM Elkins et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mannopeptimycins, new cyclic glycopeptide antibiotics produced by streptomyces hygroscopicus LL-AC98: Antibacterial and mechanistic activities
MP Singh et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
The third activity for lysyl hydroxylase 3:: galactosylation of hydroxylysyl residues in collagens in vitro
CG Wang et al.
MATRIX BIOLOGY (2002)
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
Z Hojati et al.
CHEMISTRY & BIOLOGY (2002)
Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT2440
M Manzanera et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2002)
The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine
D Eyre et al.
MOLECULAR GENETICS AND METABOLISM (2002)
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements
ZH Zhang et al.
FEBS LETTERS (2002)
Characterization of a second carotenoid β-hydroxylase gene from Arabidopsis and its relationship to the LUT1 locus
L Tian et al.
PLANT MOLECULAR BIOLOGY (2001)
Sulfonate-sulfur metabolism and its regulation in Escherichia coli
JR van der Ploeg et al.
ARCHIVES OF MICROBIOLOGY (2001)
Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase
H Ruotsalainen et al.
MATRIX BIOLOGY (2001)
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition
HS Gill et al.
BIOCHEMISTRY (2001)
Molecular characterization of co-transcribed genes from Streptomyces tendae Tu901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin
B Lauer et al.
MOLECULAR AND GENERAL GENETICS (2001)
Cloning of an isozyme of proline 3-hydroxylase and its purification from recombinant Escherichia coli
T Shibasaki et al.
BIOTECHNOLOGY LETTERS (2000)
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics
BK Hubbard et al.
CHEMISTRY & BIOLOGY (2000)
Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity
J Heikkinen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mononuclear (nitrido)iron(V) and (oxo)iron(IV) complexes via photolysis of [(cyclam-acetato)FeIII(N3)]+ and ozonolysis of [(cyclam-acetato)FeIII(O3SCF3)]+ in water/acetone mixtures
CA Grapperhaus et al.
INORGANIC CHEMISTRY (2000)
Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A -: Function of LpxO, a new Fe2+/α-ketoglutarate-dependent dioxygenase homologue
HS Gibbons et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Effect of the azetidine and azocine rings of okaramine B on insecticidal activity
Y Shiono et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2000)
Biosynthesis of the vancomycin group of antibiotics:: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine
OW Choroba et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Enzymatic production of trans-4-hydroxy-L-proline by regio- and stereospecific hydroxylation of L-proline
T Shibasaki et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2000)
Geometric and electronic structure/function correlations in non-heme iron enzymes
EI Solomon et al.
CHEMICAL REVIEWS (2000)
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism
AG Prescott et al.
NATURAL PRODUCT REPORTS (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
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