期刊
NANOTECHNOLOGY
卷 29, 期 40, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aad358
关键词
gold nanoparticles; drug delivery system; surface plasmon resonance; tumor therapy; photothermal therapy
资金
- National Natural Science Foundation [21476190, 21776238]
- Hebei province key basic research Foundation [15961301D]
- Hebei education department key project [ZD2017084]
- Qinhuangdao science and technology research and development project [201402B029]
Hybrid liposome/metal nanoparticles are promising candidate drug-carriers for therapy of various diseases due to their unique photothermal effect. In this study, self-crystallized gold nanoparticles (Au NPs) and doxorubicin (DOX) were co-encapsulated within liposomes (Au/DOX-Lips) by thin film hydration and gel separation technology. The surface plasmon resonance bands of drug-carriers were controllable in the near-infrared (NIR) zone. When the complex liposome/metallic hybrids were irradiated by NIR light, they displayed higher endocytosis efficiency following the fracture of liposomal membranes and the release of Au NPs. Then, the Au NPs penetrated further into deeper tumor tissue to accomplish photothermal treatment. The Au/DOX-Lips showed an excellent antitumor effect, whose inhibition rate for tumor cells was up to 78.28%. In experiments on mice bearing tumors, the Au/DOX-Lips treated mice exhibited superior tumor suppression. This novel drug system provides huge potential for biomedical application.
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