期刊
NANOSCALE
卷 10, 期 23, 页码 10986-10990出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr01096j
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类别
资金
- National Institutes of Health [GM079359, GM111386, CA133086]
- National Key Scientific Program of China [2011CB911000]
- NSFC [NSFC 21221003, NSFC 21327009]
- China National Instrumentation Program 2011 [YQ03012412]
We designed an aptamer-based multifunctional ligand which, upon conjugation to the surface of upconversion nanoparticles (UCNPs), could realize phase transfer, covalent photosensitizer (PS) loading, and cancer cell targeting in one simple step. The as-built PDT nanodrug is selectively internalized into cancer cells and it exhibits highly efficient and selective cytotoxicity.
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