期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 14, 期 7, 页码 2215-2226出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.06.010
关键词
Atherosclerosis; Inflammation; Oxidative stress; ROS-responsive polymers; Andrographolide
资金
- National Natural Science Foundation of China [U1401242, 31530023]
- National Basic Research Program of China [2015CB755500]
- Natural Science Foundation of the Guangdong Province [2014A030312018]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
Inflammation and oxidative stress are two major factors that are involved in the pathogenesis of atherosclerosis. A smart drug delivery system that responds to the oxidative microenvironment of atherosclerotic plaques was constructed in the present study. Andrographolide-loaded micelle was assembled from the block copolymer of poly(ethylene glycol) and poly(propylene sulphide) (PEG-PPS) for the purpose of simultaneously decreasing inflammatory response and the level of reactive oxygen species (ROS) to treat atherosclerosis. Owing to the ROS-responsive nature of PEG-PPS, the micelle not only serves as a stimuli- responsive drug carrier to quickly release the encapsulated drug, andrographolide, but also consumes ROS by itself at the pathologic sites, upon which the expressions of pro-inflammatory cytokines are effectively suppressed and oxidative stress is alleviated. Consequently, the andrographolide-loaded micelle demonstrated remarkable therapeutic effects both in vitro and in vivo. In conclusion, the andrographolide-loaded PEG-PPS micelle can synchronically alleviate inflammation and oxidative stress, providing a promising and innovative strategy against atherosclerosis. (c) 2018 Elsevier Inc. All rights reserved.
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