期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 14, 期 2, 页码 483-491出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.11.016
关键词
Mouse model; Preclinical imaging; Theranostic; Fluorescence imaging; Magnetic resonance; Engineered nanoparticles
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (PRIN project) [2012CK5RPF_006, 2012CK5RPF, 2012CK5RPF_002]
Nanoparticles (NPs) are a promising tool for in vivo multimodality imaging and theranostic applications. Hyaluronic acid (HA)-based NPs have numerous active groups that make them ideal as tumor-targeted carriers. The B-lymphoma neoplastic cells express on their surfaces a clone-specific immunoglobulin receptor (Ig-BCR). The peptide A20-36 (pA20-36) selectively binds to the Ig-BCR of A20 lymphoma cells. In this work, we demonstrated the ability of core-shell chitosan-HA-NPs decorated with pA20-36 to specifically target A20 cells and reduce the tumor burden in a murine xenograft model. We monitored tumor growth using high-frequency ultrasonography and demonstrated targeting specificity and kinetics of the NPs via in vivo fluorescent reflectance imaging. This result was also confirmed by ex vivo magnetic resonance imaging and confocal microscopy. In conclusion, we demonstrated the ability of NPs loaded with fluorescent and paramagnetic tracers to act as multimodal imaging contrast agents and hence as a non-toxic, highly specific theranostic system. (c) 2017 Elsevier Inc. All rights reserved.
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