期刊
NANOMEDICINE
卷 13, 期 8, 页码 887-898出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0395
关键词
cell cycle; combinational treatment; glioma; hyperbaric oxygen; hypoxia; hypoxia-induced; nanodrug; porous silicon nanoparticle; temozolomide; xenograft
资金
- National Natural Science Foundation of China [81573013]
- National Basic Research Program of China [2015CB931802]
- PCSIRT [IRT13016]
Aim: To study the effects of combinational treatment of hyperbaric oxygen (HBO) and nanotemozolomide in glioma. Materials & methods: Temozolomide (TMZ)-loaded porous silicon nanoparticles (TMZ/PSi NPs) were prepared. In vitro and in vivo evaluations were performed. Results: The cell uptake of TMZ/PSi NPs could be tracked by autofluorescence of porous silicon. The concentration of oxygen in tumor was improved and the antitumor rate was increased to 84.2% in the TMZ/PSi NPs combined with HBO group. The viability of hypoxia-induced glioma C6 cells was decreased and cell cycle was arrested at G2/M phase in response to TMZ/PSi NPs treatment with HBO compared with continuous treatment with hypoxia. Conclusion: The combinational treatment of TMZ/PSi NPs and HBO could be a promising therapeutic strategy for glioma.
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