期刊
NANOMEDICINE
卷 13, 期 9, 页码 1025-1036出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0370
关键词
algicidal effect; Prototheca spp.; silver nanoparticles
资金
- National Science Centre within the 'SONATA' funding scheme [2014/15/D/NZ7/01797]
Aim: To investigate the in vitro activity of silver NPs (AgNPs) against pathogenic microalgae of the Prototheca genus. Materials & methods: The antialgal potential of AgNPs against Prototheca species of both clinical and environmental origin was assessed from minimum inhibitory (algistatic) and algicidal concentrations. The in vitro cytotoxicity of AgNPs against bovine mammary epithelial cell line was evaluated by means of the standard MTT assay. Results: AgNPs showed a strong killing activity toward Prototheca algae, as the minimal algicidal concentration (MAC) values matched perfectly the corresponding minimum inhibitory concentration (MIC) values for all species (MAC = MIC, 1-4 mg/l), except P. stagnora (MIC > 8 mg/l). The concentrations inhibitory to pathogenic Prototheca spp. (MIC, 1-4 mg/l) were below the concentrations at which any toxicity in epithelial cells could be observed (CC20 > 6 mg/l). Conclusion: The study emphasizes the potential of AgNPs as a new therapeutic tool for the management of Prototheca infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据