期刊
NANOMEDICINE
卷 13, 期 7, 页码 689-702出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0308
关键词
antischistosomal activity; oral absorption; self-nanoemulsifying drug-delivery systems
资金
- Brazilian agency MCT/CNPq
- Brazilian agency FAP/DF [0193.000935/2015]
- Brazilian agency FAPEPI PP SUS [00045/2013]
- Brazilian agency CAPES
- Brazilian agency INCT-Nanobiotechnology
- Brazilian agency FAPESP [2014/02282-6, 2016/18023-5, 2016/22488-3]
Aim: To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model. Results: SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg(-1)) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoniin vivo. Conclusion: Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [GRAPHICS] .
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