期刊
NANO RESEARCH
卷 11, 期 5, 页码 2436-2449出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-017-1865-z
关键词
cobalt sulfide nanosheets; theranostic agent; photoacoustic imaging; magnetic resonance imaging; photothermal therapy
类别
资金
- National Natural Science Foundation of China (NSFC) [21473045, 51401066]
- Fundamental Research Funds from the Central University [PIRSOF HIT A201503]
- State Key Laboratory of Urban Water Resource and Environment, the Harbin Institute of Technology [2018DX04]
Theranostic nanoagents that integrate the diagnoses and therapies within a single nanomaterial are compelling in their use for highly precise and efficient antitumor treatments. Herein, polyethylene glycol (PEG)-modified cobalt sulfide nanosheets (CoS-PEG NSs) are synthesized and unitized as a powerful theranostic nanoagent for efficient photothermal conversion and multimodal imaging for the first time. We demonstrate that the obtained CoS-PEG NSs show excellent compatibility and stability in water and various physiological solutions, and can be effectively internalized by cells, but exhibit a low cytotoxicity. The CoS-PEG NSs exhibit an efficient photothermal conversion capacity, benefited from the strong near-infrared (NIR) absorption, high photothermal conversion efficiency (similar to 33.0%), and excellent photothermal stability. Importantly, the highly effective photothermal killing effect on cancer cells after exposure to CoS-PEG NSs plus laser irradiation has been confirmed by both the standard Cell Counting Kit-8 and live-dead cell staining assays, revealing a concentration-dependent photothermal therapeutic effect. Moreover, utilizing the strong NIR absorbance together with the T-2-MR contrast ability of the CoS-PEG NSs, a high-contrast triple-modal imaging, i.e., photoacoustic (PA), infrared thermal (IRT), and magnetic resonance (MR) imaging, can be achieved, suggesting a great potential for multimodal imaging to provide comprehensive cancer diagnosis. Our work introduces the first bioapplication of the CoS-PEG nano-material as a potential theranostic nanoplatform and may promote further rational design of CoS-based nanostructures for precise/efficient cancer diagnosis and therapy.
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