期刊
NANO LETTERS
卷 18, 期 6, 页码 3344-3351出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b05095
关键词
Carbon nanotubes; nanozymes; oxygenated groups; competitive inhibition; bacterial infections
类别
资金
- National Natural Science Foundation of China [21431007, 21533008]
- Frontier Science Key Program of CAS [QYZDJ-SSW-SLH052]
- Jilin Province Science and Technology Development Plan Project [20160520129JH, 20170101184JC]
Carbon nanotubes (CNTs) and their derivatives have emerged as a series of efficient biocatalysts to mimic the function of natural enzymes in recent years. However, the unsatisfiable enzymatic efficiency usually limits their practical usage ranging from materials science to biotechnology. Here, for the first time, we present the synthesis of several oxygenated-group-enriched carbon nanotubes (o-CNTs) via a facile but green approach, as well as their usage as high-performance peroxidase mimics for biocatalytic reaction. Exhaustive characterizations of the enzymatic activity of o-CNTs have been provided by exploring the accurate effect of various oxygenated groups on their surface including carbonyl, carboxyl, and hydroxyl groups. Because of the competitive inhibition effect among all of these oxygenated groups, the catalytic efficiency of o-CNTs is significantly enhanced by weakening the presence of noncatalytic sites. Furthermore, the admirable enzymatic activity of these o-CNTs has been successfully applied in the treatment of bacterial infections, and the results of both in vitro and in vivo nanozyme-mediated bacterial clearance clearly demonstrate the feasibility of o-CNTs as robust peroxidase mimics to effectively decrease the bacterial viability under physiological conditions. We believe that the present study will not only facilitate the construction of novel efficient nanozymes by rationally adjusting the degree of the competitive inhibition effect, but also broaden the biological usage of o-CNT-based nanomaterials via their satisfactory enzymatic activity.
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