期刊
NANO LETTERS
卷 18, 期 6, 页码 3328-3334出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b04812
关键词
Self-assembly; DNA nanotechnology; drug delivery; gene therapy; cancer therapy
类别
资金
- National Natural Science Foundation of China [21573051, 21708004, 51761145044]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [21721002]
- National Basic Research Program of China [2016YFA0201601]
- Beijing Municipal Science & Technology Commission [Z161100000116036]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-SLH029]
- CAS Interdisciplinary Innovation Team
- K. C. Wong Education Foundation
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
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