4.8 Article

Intracellularly Activatable Nanovasodilators To Enhance Passive Cancer Targeting Regime

期刊

NANO LETTERS
卷 18, 期 4, 页码 2637-2644

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b00495

关键词

Nitric oxide; nitrated polysaccharide; vasodilation; enhanced permeability and retention effect; drug delivery

资金

  1. Basic Science Research Programs of the National Research Foundation (NRF), Republic of Korea [20100027955, 2018R1A2B3006080]
  2. National Research Foundation of Korea [2018R1A2B3006080] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Conventional cancer targeting with nanoparticles has been based on the assumed enhanced permeability and retention (EPR) effect. The data obtained in clinical trials to date, however, have rarely supported the presence of such an effect. To address this challenge, we formulated intracellular nitric oxide-generating nanoparticles (NO-NPs) for the tumor site-specific delivery of NO, a well-known vasodilator, with the intention of boosting EPR. These nanoparticles are self-assembled under aqueous conditions from amphiphilic copolymers of poly(ethylene glycol) and nitrated dextran, which possesses inherent NO release properties in the reductive environment of cancer cells. After systemic administration of the NO-NPs, we quantitatively assessed and visualized increased tumor blood flow as well as enhanced vascular permeability than could be achieved without NO. Additionally, we prepared doxorubicin (DOX)-encapsulated NO-NPs and demonstrated consequential improvement in therapeutic efficacy over the control groups with considerably improved DOX intratumoral accumulation. Overall, this proof of concept study implies a high potency of the NO-NPs as an EPR enhancer to achieve better clinical outcomes.

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