期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 828, 期 -, 页码 15-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2018.01.009
关键词
CHO cells; Comet assay; Superoxide dismutase; Malondialdehyde; Histopathologiy
The radioprotective and antioxidant activities of melanin nanoparticles (MNP) were investigated in Chinese hamster ovary (CHO) cells in vitro and BALB/C mice in vivo. The endpoints measured were cell viability, superoxide dismutase (SOD) enzyme activity, malondialdehyde (MDA) levels, DNA damage (comet assay), and histopathological examination of tissues. Irradiated groups showed decreased SOD activity and increased MDA levels. Irradiation caused a 3-10-fold increase in comet parameters such as % tail DNA. Treatment with MNP protected cells from DNA damage and death, restored SOD activity, and decreased MDA production. Synthetic MNPs have both antioxidant and radioprotective activities.
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