期刊
MULTIPLE SCLEROSIS JOURNAL
卷 25, 期 8, 页码 1170-1177出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458518783345
关键词
Multiple sclerosis; pediatrics; etiology; risk factors; questionnaires; sunlight; vitamin D; tobacco smoke pollution
资金
- US National MS Society [5986412]
- Multiple Sclerosis International Foundation
- McGill University
- Canadian Institutes of Health Research
- MS Society of Canada
Background: While studying the etiology of multiple sclerosis (MS) in children has several methodological advantages over studying etiology in adults, studies are limited by small sample sizes. Objective: Using a rigorous methodological process, we developed the Pediatric MS Tool-Kit, a measurement framework that includes a minimal set of core variables to assess etiological risk factors. Methods: We solicited input from the International Pediatric MS Study Group to select three risk factors: environmental tobacco smoke (ETS) exposure, sun exposure, and vitamin D intake. To develop the Tool-Kit, we used a Delphi study involving a working group of epidemiologists, neurologists, and content experts from North America and Europe. Results: The Tool-Kit includes six core variables to measure ETS, six to measure sun exposure, and six to measure vitamin D intake. The Tool-Kit can be accessed online (). Conclusion: The goals of the Tool-Kit are to enhance exposure measurement in newly designed pediatric MS studies and comparability of results across studies, and in the longer term to facilitate harmonization of studies, a methodological approach that can be used to circumvent issues of small sample sizes. We believe the Tool-Kit will prove to be a valuable resource to guide pediatric MS researchers in developing study-specific questionnaire
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