期刊
HETEROCYCLES
卷 91, 期 5, 页码 1007-1016出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-15-13178
关键词
Penicillium citrinum; Penicitrinol; Penicillenol; Marine-Derived Fungus; Cytotoxicity
资金
- Chinese National Natural Science Fund [21102015, 31201034]
- Ministry of Sanitation [WKJ-FJ-14]
- Ministry of Education in Fujian Province [WKJ-FJ-14]
- Natural Science Foundation of Fujian Province [2014J01301]
- Department of Science and Technology in Fujian Province [2012Y0017]
Six new compounds, penicitrinols L-O (1-4), penicillenols D-1 (9) and D-2 (10), together with six known compounds were isolated from the marine-derived fungus Penicillium citrinum. Their structures were elucidated on the basis of comprehensive spectral analysis and chemical methods. All the new compounds were evaluated for their cytotoxic effects on the A-549, HL-60 and SW-620 cell lines by the MTT method. Penicitrinols L (1) and M (2) showed weak cytotoxicities against SW-620 cell line, while penicillenols D-1 (9) and D-2 (10) showed weak cytotoxicities against A-549 and HL-60 cell lines, respectively.
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