期刊
NATURE REVIEWS CANCER
卷 13, 期 10, 页码 727-738出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3597
关键词
-
类别
资金
- FNRS
- Interuniversity Attraction Poles programme
- ARC programme (Action de Recherche Concertee)
- Fondation Contre le Cancer
- Universite Libre de Bruxelles fondation
- fond Gaston Ithier
- European Research Council
The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro clonogenic assays, transplantation and in vivo lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据