期刊
MONATSHEFTE FUR CHEMIE
卷 149, 期 7, 页码 1199-1245出版社
SPRINGER WIEN
DOI: 10.1007/s00706-018-2215-x
关键词
Antibiotics; Antitumor agents; Antiviral activity; Conjugates; Drug research; Hybrid drugs
资金
- National Science Centre, Poland [2016/21/N/NZ7/03464]
This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a variety of applications ranging from metal complexes and nanoparticle development to hybrid conjugates with therapeutic uses. The review covers the literature from the past 10 years with emphasis placed on new applications and mechanisms of pharmacological action of quinolone derivatives. The following are considered: metal complexes, nanoparticles and nanodrugs, polymers, proteins and peptides, NO donors and analogs, anionic compounds, siderophores, phosphonates, and prodrugs with enhanced lipophilicity, phototherapeutics, fluorescent compounds, triazoles, hybrid drugs, bis-quinolones, and other modifications. This review provides a comprehensive resource, summarizing a broad range of important quinolone applications with great utility as a resource concerning both chemical modifications and also novel hybrid bifunctional therapeutic agents. [GRAPHICS] .
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