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FREE RADICAL RESEARCH (2008)
Peroxynitrite Damages U937 Cell DNA via the Intermediate Formation of Mitochondrial Oxidants
Orazio Cantoni et al.
IUBMB LIFE (2008)
DNA adducts with lipid peroxidation products
Ian A. Blair
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta
Ryuhei Nagai et al.
JOURNAL OF PINEAL RESEARCH (2008)
Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes
Igor Semak et al.
JOURNAL OF PINEAL RESEARCH (2008)
Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK
Kailash Manda et al.
JOURNAL OF PINEAL RESEARCH (2008)
Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
Daniel Gackowski et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)
A Role for Oxidized DNA Precursors in Huntington's Disease-Like Striatal Neurodegeneration
Gabriele De Luca et al.
PLOS GENETICS (2008)
Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines
Conor Crean et al.
NUCLEIC ACIDS RESEARCH (2008)
Melatonin, endocrine pancreas and diabetes
Elmar Peschke
JOURNAL OF PINEAL RESEARCH (2008)
Protective action of melatonin against oxidative DNA damage - Chemical inactivation versus base-excision repair
Tomasz Sliwinski et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2007)
Biochemistry of oxidative stress
B. Halliwell
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Reactions of the NO redox forms NO+, •NO and HNO (protonated NO-) with the melatonin metabolite N1-acetyl-5-methoxykynuramine
Ruediger Hardeland et al.
JOURNAL OF PINEAL RESEARCH (2007)
N1-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging:: cyclization to a cinnolinone prevents formation of unstable nitrosamines
R. Hardeland et al.
JOURNAL OF PINEAL RESEARCH (2007)
UVB-Induced formation of intrastrand cross-link products of DNA in MCF-7 cells treated with 5-bromo-2'-deoxyuridine
Yu Zeng et al.
BIOCHEMISTRY (2007)
AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice
Kailash Manda et al.
JOURNAL OF PINEAL RESEARCH (2007)
Increased DNA damage and oxidative stress in patients with rheumatoid arthritis
Ozlem Altindag et al.
CLINICAL BIOCHEMISTRY (2007)
Nitric oxide and peroxynitrite in health and disease
Pal Pacher et al.
PHYSIOLOGICAL REVIEWS (2007)
One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
Dun-Xian Tan et al.
JOURNAL OF PINEAL RESEARCH (2007)
Free radicals and antioxidants in normal physiological functions and human disease
Marian Valko et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Marcelo Genestra
CELLULAR SIGNALLING (2007)
Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2-substituted 3-indolinones
Joachim Rosen et al.
JOURNAL OF PINEAL RESEARCH (2006)
DNA oxidation in Alzheimer's disease
William R. Markesbery et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Microcystin-induced 8-hydroxydeoxyguanosine in DNA and its reduction by melatonin, vitamin C, and vitamin E in mice
S. Al-jassabi et al.
BIOCHEMISTRY-MOSCOW (2006)
Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin
Josefa Leon et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives:: discussion on possible antioxidant mechanisms and comparison with melatonin
Sibel Suzen et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2006)
Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure
Yasuyuki Kono et al.
CIRCULATION JOURNAL (2006)
Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems
Tobias W. Fischer et al.
FASEB JOURNAL (2006)
Melatonin directly scavenges free radicals generated in red blood cells and a cell-free system: Chemiluminescence measurements and theoretical calculations
I. B. Zavodnik et al.
LIFE SCIENCES (2006)
Free radicals, metals and antioxidants in oxidative stress-induced cancer
M Valko et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity
DS Maharaj et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite
HB Yu et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2005)
Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation
C Badouard et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)
Occupational exposure to mercury vapour on genotoxicity and DNA repair
A Cebulska-Wasiewska et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2005)
Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species:: Formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK
AL Guenther et al.
JOURNAL OF PINEAL RESEARCH (2005)
Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro
LJ Chen et al.
JOURNAL OF PINEAL RESEARCH (2005)
6-Hydroxymelatonin protects against quinolinic-acid-induced oxidative neurotoxicity in the rat hippocampus
DS Maharaj et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2005)
Antioxidative protection by melatonin - Multiplicity of mechanisms from radical detoxification to radical avoidance
R Hardeland
ENDOCRINE (2005)
A review of the multiple actions of melatonin on the immune system
A Carrillo-Vico et al.
ENDOCRINE (2005)
Oxidative DNA injury after experimental intracerebral hemorrhage
T Nakamura et al.
BRAIN RESEARCH (2005)
Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, quercetin or resveratrol
J Onuki et al.
JOURNAL OF PINEAL RESEARCH (2005)
A comparative study: Evaluation of antioxidant activity of melatonin and some indole derivatives
Z Ates-Alagoz et al.
MEDICINAL CHEMISTRY RESEARCH (2005)
Caffeic acid phenethyl ester modulates 1800 MHz microwave-induced oxidative stress in rat liver
A Koyu et al.
ELECTROMAGNETIC BIOLOGY AND MEDICINE (2005)
A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
C Tomas-Zapico et al.
JOURNAL OF PINEAL RESEARCH (2005)
Metals, toxicity and oxidative stress
M Valko et al.
CURRENT MEDICINAL CHEMISTRY (2005)
XRCC1 is required for DNA single-strand break repair in human cells
R Brem et al.
NUCLEIC ACIDS RESEARCH (2005)
Age-related changes in serum melatonin in mice: higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues
DK Lahiri et al.
JOURNAL OF PINEAL RESEARCH (2004)
Hypochlorous acid-induced oxidative stress in Chinese hamster B14 cells: viability, DNA and protein damage and the protective action of melatonin
IB Zavodnik et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2004)
Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain
Ü Ündeger et al.
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2004)
Reactive nitrogen species in the chemical biology of inflammation
PC Dedon et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Oxidative DNA damage and disease: induction, repair and significance
MD Evans et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2004)
Effects of melatonin on the nitric oxide treated retina
AW Siu et al.
BRITISH JOURNAL OF OPHTHALMOLOGY (2004)
Endogenous formation of novel halogenated 2′-deoxycytidine -: Hypohalous acid-mediated DNA modification at the site of inflammation
Y Kawai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite:: Mechanistic studies with 18O
JC Niles et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Antioxidants and prevention of chronic disease
JK Willcox et al.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2004)
Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling
A Behrends et al.
REDOX REPORT (2004)
Mechanism of arsenic carcinogenesis: an integrated approach
Toby G. Rossman
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Melatonin: structural characterization of its non-enzymatic mono-oxygenate metabolite
P Agozzino et al.
JOURNAL OF PINEAL RESEARCH (2003)
Independent generation of 5-(2′-deoxycytidinyl)methyl radical and the formation of a novel cross-link lesion between 5-methylcytosine and guanine
QB Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates
DS Maharaj et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2003)
Melatonin prevents free radical formation due to the interaction between β-amyloid peptides and metal ions [Al(III), Zn(II), Cu(II), Mn(II), Fe(II)]
P Zatta et al.
JOURNAL OF PINEAL RESEARCH (2003)
Oxidative DNA damage: mechanisms, mutation, and disease
MS Cooke et al.
FASEB JOURNAL (2003)
In vivo and in vitro effects of melatonin or ganglioside GT1B on L-cysteine-induced brain mitochondrial DNA damage in mice
H Yamamoto et al.
TOXICOLOGICAL SCIENCES (2003)
Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical
DX Tan et al.
JOURNAL OF PINEAL RESEARCH (2003)
Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and α-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents:: a study of their individual and synergistic actions
S López-Burillo et al.
JOURNAL OF PINEAL RESEARCH (2003)
Melatonin and its derivatives cyclic 3-hydroxymelatonin, N1-acetyl-N 2-formyl-5-methoxykynuramine and 6-methoxymelatonin reduce oxidative DNA damage induced by Fenton reagents
S López-Burillo et al.
JOURNAL OF PINEAL RESEARCH (2003)
Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants
JC Mayo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2003)
Melatonin prevents the increase in hydroxyl radical-spin trap adduct formation caused by the addition of cisplatin in vitro
M Yoshida et al.
LIFE SCIENCES (2003)
Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice
H Yamamoto et al.
BRAIN RESEARCH (2003)
6-hydroxymelatonin converts Fe (III) to Fe (II) and reduces iron-induced lipid peroxidation
DS Maharaj et al.
LIFE SCIENCES (2003)
Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis
S Hajizadeh et al.
ARTHRITIS RESEARCH & THERAPY (2003)
Antioxidant properties of the melatonin metabolite N-1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction
AR Ressmeyer et al.
REDOX REPORT (2003)
Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage
R Hardeland et al.
JOURNAL OF PINEAL RESEARCH (2003)
Melatonin protects against mercury(II)-induced oxidative tissue damage in rats
G Sener et al.
PHARMACOLOGY & TOXICOLOGY (2003)
Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected
JG Hengstler et al.
CARCINOGENESIS (2003)
Melatonin: reducing the toxicity and increasing the efficacy of drugs
RJ Reiter et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2002)
Further insights into the reaction of melatonin with hydroxyl radical
JA Horstman et al.
BIOORGANIC CHEMISTRY (2002)
Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro
HA Yamamoto et al.
TOXICOLOGY (2002)
Apoptotic molecules and MPTP-induced cell death
A Nicotra et al.
NEUROTOXICOLOGY AND TERATOLOGY (2002)
DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way
D Kulms et al.
ONCOGENE (2002)
Oxidative DNA damage: Assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome
R Olinski et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Melatonin as an effective protector against doxorubicin-induced cardiotoxicity
XW Liu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis
KS Kasprzak
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Melatonin protects against copper-mediated free radical damage
P Parmar et al.
JOURNAL OF PINEAL RESEARCH (2002)
The identification of the UV degradants of melatonin and their ability to scavenge free radicals
DS Maharaj et al.
JOURNAL OF PINEAL RESEARCH (2002)
Cross-linked thymine-purine base tandem lesions:: Synthesis, characterization, and measurement in γ-irradiated isolated DNA
S Bellon et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid
PV Mohanan et al.
TOXICOLOGY LETTERS (2002)
Melatonin reduces phosphine-induced lipid and DNA oxidation in vitro and in vivo in rat brain
CH Hsu et al.
JOURNAL OF PINEAL RESEARCH (2002)
MPTP: a review of its mechanisms of neurotoxicity
S Przedborski et al.
CLINICAL NEUROSCIENCE RESEARCH (2001)
Autoxidation and toxicant-induced oxidation of lipid and DNA in monkey liver: Reduction of molecular damage by melatonin
J Cabrera et al.
PHARMACOLOGY & TOXICOLOGY (2001)
Preventive effect of melatonin against DNA damage induced by cyanide, kainate, glutathione/Fe3+/O2, or H2O2/Fe2+
HA Yamamoto et al.
JOURNAL OF PINEAL RESEARCH (2001)
Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice
MV Rao et al.
REPRODUCTIVE TOXICOLOGY (2001)
Protective effect of melatonin against in vitro iron ions and 7 mT 50 Hz magnetic field-induced DNA damage in rat lymphocytes
J Jajte et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2001)
N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid
JJ García et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
DNA oxidatively damaged by chromium(III) and H2O2 is protected by the antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid
S Burkhardt et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)
N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
DX Tan et al.
FASEB JOURNAL (2001)
Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model
WC Luo et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Protective effect of melatonin on naphthalene-induced oxidative stress and DNA damage in cultured macrophage J774A.1 cells
M Bagchi et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2001)
Antioxidants in health and disease
IS Young et al.
JOURNAL OF CLINICAL PATHOLOGY (2001)
Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage
M Karbownik et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2001)
Melatonin prevents δ-aminolevulinic acid-induced oxidative DNA damage in the presence of Fe2+
WB Qi et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2001)
Myeloperoxidase-catalyzed oxidation of melatonin by activated neutrophils
SO Silva et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation
DX Tan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Actions of melatonin in the reduction of oxidative stress - A review
RJ Reiter et al.
JOURNAL OF BIOMEDICAL SCIENCE (2000)
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair:: the 3′ ends justify the means
CD Mol et al.
MUTATION RESEARCH-DNA REPAIR (2000)
Increased levels of oxidatively damaged DNA induced by chromium(III) and H2O2:: protection by melatonin and related molecules
WB Qi et al.
JOURNAL OF PINEAL RESEARCH (2000)
Protective effect of melatonin on methylmercury-induced mortality in mice
CY Kim et al.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation
M Karbownik et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2000)
Mitochondrial DNA damage and a hypoxic response are induced by CoCI2 in rat neuronal PC12 cells
GC Wang et al.
NUCLEIC ACIDS RESEARCH (2000)
Nitrite-induced deamination and hypochlorite-induced oxidation of DNA in intact human respiratory tract epithelial cells
JPE Spencer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
The trap depth (in DNA) of 8-oxo-7,8-dihydro-2′deoxyguanosine as derived from electron-transfer equilibria in aqueous solution
S Steenken et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Copper-ligand interactions and physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copper-driven fenton chemistry in vitro
S Gaubert et al.
FREE RADICAL RESEARCH (2000)
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